The results from many studies indicate that most solid tumors, regardless of site of origin,
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …

Many human tumors contain a significant fraction of hypoxic cells that can directly affect
responsiveness to therapy. Evidence is increasing that hypoxia may also contribute to …

Regions of reduced oxygenation (hypoxia) are a characteristic feature of virtually all animal
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …

Most histopathological classifications of human cancers include significant numbers of
hypoxic cells. There is increasing evidence that, at least in certain types of human solid …

Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …

Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …