[HTML][HTML] The antinociceptive effect of anterior pretectal nucleus stimulation is mediated by distinct neurotransmitter mechanisms in descending pain pathways

K Genaro, D Fabris, WA Prado - Brain Research Bulletin, 2019 - Elsevier
Electrical stimulation of the anterior pretectal nucleus (APtN) activates two descending pain
inhibitory pathways. One of these pathways relays in the ipsilateral lateral …

[HTML][HTML] Neural correlates of the antinociceptive effects of stimulating the anterior pretectal nucleus in rats

K Genaro, WA Prado - The Journal of Pain, 2016 - Elsevier
Stimulation-evoked antinociception (SEA) from the anterior pretectal nucleus (APtN)
activates mechanisms that descend to the spinal cord through the dorsolateral funiculus, but …

Participation of brainstem nuclei in the pronociceptive effect of lesion or neural block of the anterior pretectal nucleus in a rat model of incisional pain

CF Villarreal, VAV Kina, WA Prado - Neuropharmacology, 2004 - Elsevier
The anterior pretectal nucleus (APtN) participates in nociceptive process and controls spinal
nociceptive inputs, and its integrity reduces the severity of the responses to persistent injury …

Antinociception induced by stimulating the anterior pretectal nucleus in two models of pain in rats

CF Villarreal, VAV Kina… - Clinical and experimental …, 2004 - Wiley Online Library
This study examined whether different parts of the rat anterior pretectal nucleus (APtN) may
be involved in the spinal control of brief (tail flick test) or persistent (surgical incision of the …

The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones

MG Terenzi, H Rees, SJS Morgan, GA Foster… - Pain, 1991 - Elsevier
Electrical stimulation (35 μA rms/15 s) of the anterior pretectal nucleus (APtN) inhibits the
spinal reflex of the tail-flick (TF) to noxious heat in unanaesthetised rats. APtN stimulation …

The role of the anterior pretectal nucleus in pain modulation: A comprehensive review

K Genaro, WA Prado - European Journal of Neuroscience, 2021 - Wiley Online Library
Descending pain modulation involves multiple encephalic sites and pathways that range
from the cerebral cortex to the spinal cord. Behavioral studies conducted in the 1980s …

The pontine parabrachial region mediates some of the descending inhibitory effects of stimulating the anterior pretectal nucleus

MG Terenzi, H Rees, MHT Roberts - Brain research, 1992 - Elsevier
Electrical stimulation of the anterior pretectal nucleus (APtN) elicits antinociception by
inhibiting the responses of spinal multireceptive neurones to noxious stimuli. This …

[HTML][HTML] Stimulation-produced analgesia from the occipital or retrosplenial cortex of rats involves serotonergic and opioid mechanisms in the anterior pretectal nucleus

GM Reis, AC Rossaneis, JWS Silveira, QM Dias… - The Journal of …, 2011 - Elsevier
The electrical stimulation of the occipital (OC) or retrosplenial (RSC) cortex produces
antinociception in the rat tail-flick test. These cortices send inputs to the anterior pretectal …

Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats

AC Rossaneis, K Genaro, QM Dias… - … Journal of Pain, 2015 - Wiley Online Library
Background The anterior pretectal nucleus (APtN) activates descending mechanisms of pain
control. This study evaluated whether the APtN also controls neuropathic pain in rats …

[HTML][HTML] μ1-and 5-HT1-dependent mechanisms in the anterior pretectal nucleus mediate the antinociceptive effects of retrosplenial cortex stimulation in rats

GM Reis, AC Rossaneis, JWS Silveira, WA Prado - Life sciences, 2012 - Elsevier
AIM: This study examines if injection of cobalt chloride (CoCl2) or antagonists of muscarinic
cholinergic (atropine), μ1-opioid (naloxonazine) or 5-HT1 serotonergic (methiothepin) …