Introduction Chondroitin sulfate (CS) is a symptomatic slow-acting drug for osteoarthritis
(OA) widely used in the clinic. The aim of this work is to find proteins whose secretion from …

CNS damage often results in demyelination of spared axons due to oligodendroglial cell
death and dysfunction near the injury site. Although new oligodendroglia are generated …

Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar
formed after severe traumatic brain injury as well as spinal cord injury and play a crucial …

Background Glucosamine and chondroitin sulfate preparations are widely used as food
supplements against osteoarthritis, but critics are skeptical about their efficacy, because of …

Chondroitin sulphate proteoglycans (CSPGs), consisting of core proteins linked to one or
more chondroitin sulphate (CS) chains, are major extracellular matrix (ECM) components of …

After injury to the mammalian central nervous system (CNS), neurons are not able to
regenerate their axons and recovery is limited by restricted plasticity. Axon regeneration is …

Previous studies reported that hyaluronic acid (HA), chondroitin sulphate (CS) and heparan
sulphate (HS) were able to reduce the inflammatory process in a variety of cell types after …

Background: Chondroitin sulfates (CS) are involved in articular metabolism and could be
used as therapeutic agents in degenerative articular diseases. Objectives: To review the …

Proteoglycans are of two main types, chondroitin sulfate (CSPGs) and heparin sulfate
(HSPGs). The CSPGs act mainly as barrier-forming molecules, whereas the HSPGs stabilise …

Activation of microglial cells, the resident immune cells of the CNS causes neurotoxicity
through the release of a wide array of inflammatory mediators including proinflammatory …