Is there a rationale for cortisol-based treatments for PTSD?

R Yehuda, J Golier - Expert review of neurotherapeutics, 2009 - Taylor & Francis
At the current time, there are few effective pharmacotherapy options for posttraumatic stress
disorder (PTSD), and no medication strategies targeted towards PTSD prophylaxis. This in …

Neuroendocrine aspects of PTSD

R Yehuda - Anxiety and anxiolytic drugs, 2005 - Springer
This chapter discussed how neuroendocrine findings in posttraumatic stress disorder
(PTSD) potentially inform hypothalamic-pituitary-adrenal (HPA) alterations in PTSD and …

[PDF][PDF] Endocrine aspects of PTSD: Hypothalamic-pituitary-adrenal (HPA) axis and beyond

NP Daskalakis, MA McGill, A Lehrner… - … guide to post-traumatic …, 2016 - researchgate.net
Post-traumatic stress disorder is a severe, debilitating mental disorder with multiple
symptoms that span biological systems and present with medical comorbidities. This …

Neuroendocrinological treatment targets for posttraumatic stress disorder

S Yoon, YK Kim - Progress in Neuro-Psychopharmacology and …, 2019 - Elsevier
Posttraumatic stress disorder (PTSD) is prevalent, disabling, and frequently becomes
chronic. Despite this, only two selective serotonergic reuptake inhibitors have been …

Cortisol and the hypothalamic–pituitary–adrenal axis in PTSD

A Lehrner, N Daskalakis… - Posttraumatic Stress …, 2016 - Wiley Online Library
The acute stress response includes activation of the hypothalamic‐pituitary‐adrenal (HPA)
axis, which leads to the release of cortisol, a glucocorticoid. Through negative feedback …

Glucocorticoid-based pharmacotherapies preventing PTSD

A Florido, ER Velasco, S Monari, M Cano… - …, 2023 - Elsevier
Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may
arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder …

The Role of Cortisol in Development and Treatment of PTSD Among Service Members: A Narrative Review

KH Buccellato, AL Peterson - Psychoneuroendocrinology, 2024 - Elsevier
Posttraumatic stress disorder (PTSD) is a pervasive issue within military populations, with
approximately 29% of post-9/11 service members experience PTSD at some point in their …

Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications

R Yehuda - Annals of the new York Academy of Sciences, 2006 - Wiley Online Library
The findings from investigations of the neuroendocrinology of posttraumatic stress disorder
(PTSD) have highlighted alterations that have not historically been associated with …

Considering future pharmacotherapy for PTSD

MJ Friedman, NC Bernardy - Neuroscience letters, 2017 - Elsevier
Posttraumatic stress disorder (PTSD) is a prevalent, disabling, and often chronic condition
that may develop following exposure to a traumatic event. Despite the immense social and …

[HTML][HTML] Biological markers in clinical psychological research-A systematic framework applied to HPA axis regulation in PTSD

S Engel, H Klusmann, S Laufer, C Kapp… - Comprehensive …, 2022 - Elsevier
Biological markers, particularly endocrine measurements, are increasingly being integrated
into clinical psychological research. We introduce a systematic framework that classifies …