High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …

RNA splicing, the enzymatic process of removing segments of premature RNA to produce
mature RNA, is a key mediator of proteome diversity and regulator of gene expression …

There has been accumulating evidence that RNA splicing is frequently dysregulated in a
variety of cancers and that hotspot mutations affecting key splicing factors, SF3B1, SRSF2 …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

RNA splicing dysregulation is widespread in cancer. Accumulating evidence demonstrates
that splicing defects resulting from splicing dysregulation play critical roles in cancer …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional
variants from individual genes. Various cell types and developmental stages regulate …

Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …

Recent progress in global sequence and microarray data analysis has revealed the
increasing complexity of the human transcriptome. Alternative splicing generates a huge …