The human body associates sensory cues with metabolic consequences. Exposure to sweet-
tasting sugars–even in the absence of ingestion–triggers physiological responses that are …

Until recently, the general belief was that non-nutritive sweeteners (NNSs) were healthy
sugar substitutes because they provide sweet taste without calories or glycemic effects …

The consumption of non-nutritive, low, or no-calorie sweeteners (LCS) is increasing globally.
Previously thought to be physiologically inert, there is a growing body of evidence that LCS …

Background: Glucose is a natural ligand for sweet taste receptors (STRs) that are expressed
on the tongue and in the gastrointestinal tract. Whether STRs directly contribute to the …

Context: Non-nutritive sweeteners can bind to sweet-taste receptors present not only in the
oral cavity, but also on enteroendocrine and pancreatic islet cells. Thus, these sweeteners …

Abstract Background/objectives Nonnutritive sweeteners (NNSs) are zero-or low-calorie
alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta …

Objective: Many scientists and laypeople alike have concerns about low‐calorie sweeteners
(LCSs). These concerns stem from both a dissatisfaction with the taste of LCSs and reports …

Background: There has been an emerging concern that non-nutritive sweeteners (NNS) can
increase the risk of cardiometabolic disease. Much of the attention has focused on acute …

Non-nutritive sweeteners, energy balance, and glucose homeos... : Current Opinion in Clinical
Nutrition & Metabolic Care Non-nutritive sweeteners, energy balance, and glucose homeostasis …

Nonnutritive sweeteners (NNS) are ecologically novel chemosensory signaling compounds
that influence ingestive processes and behavior. Only about 15% of the US population …