A comparative molecular dynamics analysis of the amyloid β-peptide in a lipid bilayer
Because the amyloid β-peptide (Aβ) functions as approximately half of the transmembrane
domain of the amyloid precursor protein and interaction of Aβ with membranes is proposed …
domain of the amyloid precursor protein and interaction of Aβ with membranes is proposed …
Interaction between amyloid-β (1–42) peptide and phospholipid bilayers: a molecular dynamics study
CH Davis, ML Berkowitz - Biophysical journal, 2009 - cell.com
The amyloid-β (Aβ) peptide is a key aggregate species in Alzheimer's disease. Although
important aspects of Aβ peptide aggregation are understood, the initial stage of aggregation …
important aspects of Aβ peptide aggregation are understood, the initial stage of aggregation …
Perturbation of membranes by the amyloid β‐peptide–a molecular dynamics study
The etiology of Alzheimer's disease is considered to be linked to interactions between
amyloid β‐peptide (Aβ) and neural cell membranes. Membrane disruption and increased …
amyloid β‐peptide (Aβ) and neural cell membranes. Membrane disruption and increased …
Molecular dynamics simulations reveal the protective role of cholesterol in β-amyloid protein-induced membrane disruptions in neuronal membrane mimics
L Qiu, C Buie, A Reay, MW Vaughn… - The Journal of Physical …, 2011 - ACS Publications
Interactions of β-amyloid (Aβ) peptides with neuronal membranes have been associated
with the pathogenesis of Alzheimer's disease (AD); however, the molecular details remain …
with the pathogenesis of Alzheimer's disease (AD); however, the molecular details remain …
[HTML][HTML] How the amyloid-β peptide and membranes affect each other: an extensive simulation study
The etiology of Alzheimer's disease is thought to be linked to interactions between amyloid-β
(Aβ) and neural cell membranes, causing membrane disruption and increased ion …
(Aβ) and neural cell membranes, causing membrane disruption and increased ion …
Conformational transition of amyloid β-peptide
Y Xu, J Shen, X Luo, W Zhu, K Chen… - Proceedings of the …, 2005 - National Acad Sciences
The amyloid β-peptides (Aβs), containing 39–43 residues, are the key protein components
of amyloid deposits in Alzheimer's disease. To structurally characterize the dynamic …
of amyloid deposits in Alzheimer's disease. To structurally characterize the dynamic …
Aggregation of Alzheimer's amyloid β-peptide in biological membranes: A molecular dynamics study
Numerous studies have concluded that the interaction of the amyloid β-peptide (Aβ) and
cellular membranes contributes to the toxicity and cell death observed in the progression of …
cellular membranes contributes to the toxicity and cell death observed in the progression of …
Modelling of interactions between Aβ (25–35) peptide and phospholipid bilayers: effects of cholesterol and lipid saturation
I Ermilova, AP Lyubartsev - RSC advances, 2020 - pubs.rsc.org
Aggregation of amyloid beta (Aβ) peptides in neuronal membranes is a known promoter of
Alzheimer's disease. To gain insight into the molecular details of Aβ peptide aggregation …
Alzheimer's disease. To gain insight into the molecular details of Aβ peptide aggregation …
Binding of cytotoxic Aβ25–35 peptide to the dimyristoylphosphatidylcholine lipid bilayer
AK Smith, DK Klimov - Journal of Chemical Information and …, 2018 - ACS Publications
Aβ25–35 is a short, cytotoxic, and naturally occurring fragment of the Alzheimer's Aβ
peptide. To map the molecular mechanism of Aβ25–35 binding to the zwitterionic …
peptide. To map the molecular mechanism of Aβ25–35 binding to the zwitterionic …
Alzheimer Aβ peptide interactions with lipid membranes: fibrils, oligomers and polymorphic amyloid channels
F Tofoleanu, NV Buchete - Prion, 2012 - Taylor & Francis
Fibrillar aggregates of misfolded amyloid proteins are involved in a variety of diseases such
as Alzheimer disease (AD), type 2 diabetes, Parkinson, Huntington and prion-related …
as Alzheimer disease (AD), type 2 diabetes, Parkinson, Huntington and prion-related …