Leptin and gastro‐intestinal malignancies

JM Howard, GP Pidgeon, JV Reynolds - Obesity Reviews, 2010 - Wiley Online Library
Obesity is a well‐established risk factor for the development and mortality from several
cancers, including adenocarcinoma of the oesophagus, oesophago‐gastric junction and …

Obesity and cancer: Focus on leptin

K Ayed, L Nabi, R Akrout, H Mrizak, A Gorrab… - Molecular biology …, 2023 - Springer
Over the past decades, obesity has grown to epidemic proportions worldwide. It has been
associated with an increased risk for different types of cancer. In addition, obesity has been …

Leptin is a growth factor for colonic epithelial cells

JCH Hardwick, GR Van Den Brink, GJ Offerhaus… - Gastroenterology, 2001 - Elsevier
Background & Aims: Obesity increases the risk of colon cancer, whereas physical activity
reduces the risk. Plasma levels of leptin increase in proportion to the level of obesity and are …

The role of leptin in gastric cancer: clinicopathologic features and molecular mechanisms

KN Lee, HS Choi, SY Yang, HK Park, YY Lee… - Biochemical and …, 2014 - Elsevier
Obesity is associated with certain types of cancer, including gastric cancer. However, it is still
unclear whether obesity-related cytokine, leptin, is implicated in gastric cancer. Therefore …

Leptin and cancer

C Garofalo, E Surmacz - Journal of cellular physiology, 2006 - Wiley Online Library
The prevalence of obesity has markedly increased over the past two decades, especially in
the industrialized countries. While the impact of excess body weight on the development of …

Molecular mechanisms linking adipokines to obesity-related colon cancer: focus on leptin

JE Drew - Proceedings of the Nutrition Society, 2012 - cambridge.org
Obesity is linked to increased risk of colon cancer, currently the third most common cancer.
Consequently rising levels of obesity worldwide are likely to significantly impact on obesity …

Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis

H Endo, K Hosono, T Uchiyama, E Sakai, M Sugiyama… - Gut, 2011 - gut.bmj.com
Background and aims Obesity increases the risk of colorectal cancer (CRC). Serum leptin
levels are markedly elevated in obese individuals, but the involvement of leptin in CRC …

Circulating leptin and inflammatory response in esophageal cancer, esophageal cancer-related cachexia–anorexia syndrome (CAS) and non-malignant CAS of the …

D Diakowska, M Krzystek-Korpacka… - Cytokine, 2010 - Elsevier
We investigated the association between esophageal cancer and cachexia–anorexia
syndrome (CAS) of the alimentary tract and leptin, an adipocytokine crucial for body weight …

Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer

V Marques, F Arella, MB Afonso, AA Santos… - Clinical …, 2023 - portlandpress.com
The increasing prevalence of obesity brings forward its importance as a risk factor for cancer
development, particularly in the gastrointestinal tract. Obesity may trigger cancer …

[HTML][HTML] Leptin: A heavyweight player in obesity-related cancers

A Caruso, L Gelsomino, S Panza, FM Accattatis… - Biomolecules, 2023 - mdpi.com
Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has
reached pandemic proportions and is recognized as an important health concern since it is …