3He MRI in healthy volunteers: preliminary correlation with smoking history and lung volumes

D Guenther, B Eberle, J Hast, J Lill… - NMR in Biomedicine …, 2000 - Wiley Online Library
Abstract MRI with hyperpolarized helium‐3 (3He) provides high‐resolution imaging of
ventilated airspaces. The first aim of this 3He‐study was to compare observations of …

Elucidation of structure–function relationships in the lung: contributions from hyperpolarized 3helium MRI

HU Kauczor, B Eberle - Clinical physiology and functional …, 2002 - Wiley Online Library
Magnetic resonance imaging (MRI) using hyperpolarized 3helium (He) gas as the source of
signal provides new physiological insights into the structure–function relationships of the …

Imaging of the lungs using 3He MRI: preliminary clinical experience in 18 patients with and without lung disease

HU Kauczor, M Ebert, KF Kreitner… - Journal of Magnetic …, 1997 - Wiley Online Library
The purpose of this study was to describe the 3He MRI findings of normal pulmonary
ventilation in healthy volunteers and to evaluate abnormalities in patients with different lung …

Dynamic echo planar MR imaging of lung ventilation with hyperpolarized 3He in normal subjects and patients with severe emphysema

DS Gierada, B Saam, D Yablonskiy… - NMR in Biomedicine …, 2000 - Wiley Online Library
We applied the rapid imaging capability of echo planar MR pulse sequences and
hyperpolarized 3He ventilation imaging to observe the dynamic distribution of gas in the …

Hyperpolarized helium-3 gas magnetic resonance imaging of the lung

HU Kauczor - Topics in Magnetic Resonance Imaging, 2003 - journals.lww.com
Abstract 3 He magnetic resonance imaging (MRI) is capable of producing new and regional
information on normal and abnormal lung ventilation. The basis of 3 He MRI involves …

MR tagging of human lungs using hyperpolarized 3He gas

JR Owers‐Bradley, MS Fichele… - Journal of Magnetic …, 2003 - Wiley Online Library
Purpose To evaluate the use of spin‐tagging in conjunction with hyperpolarized gas
imaging for monitoring lung ventilation and gas diffusion. Methods and Materials Images …

Assessment of a single‐acquisition imaging sequence for oxygen‐sensitive 3He‐MRI

AJ Deninger, B Eberle, J Bermuth… - … in Medicine: An …, 2002 - Wiley Online Library
MRI of the lungs using hyperpolarized helium‐3 (3He) allows the determination of
intrapulmonary oxygen partial pressures (pO2). The need to separate competing processes …

Imaging physiological parameters with hyperpolarized gas MRI

SJ Kadlecek, K Emami, MC Fischer, M Ishii, J Yu… - Progress in Nuclear …, 2005 - Elsevier
Traditional magnetic resonance imaging (MRI) uses the NMR signal from protons to obtain
images in the human body. The technique enables detailed imaging of brain and soft tissue …

Comparison between 2D and 3D gradient‐echo sequences for MRI of human lung ventilation with hyperpolarized 3He

JM Wild, N Woodhouse, MNJ Paley… - … in Medicine: An …, 2004 - Wiley Online Library
Images of hyperpolarized 3He were acquired during breath‐hold in four healthy volunteers
with the use of an optimized 3D gradient‐echo sequence. The images were compared with …

Imaging of lung function using hyperpolarized helium‐3 magnetic resonance imaging: review of current and emerging translational methods and applications

S Fain, ML Schiebler, DG McCormack… - Journal of magnetic …, 2010 - Wiley Online Library
During the past several years there has been extensive development and application of
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …