Statins elicit numerous favorable effects on central nervous system (CNS) injury, including
inhibition of the rhoA/ROCK pathway. In the present study, we show that statins decrease …

Object The authors' previous studies have demonstrated that simvastatin treatment promotes
neuronal survival and reduces inflammatory cytokine release from astrocytes after traumatic …

The treatment of traumatic brain injury (TBI) remains limited, and aside from surgical
hematoma evacuation, clinical management is largely supportive and directed toward …

BACKGROUND Statins have therapeutic benefits for the management of several disorders.
A short-term course of a high-dose statin pretreatment has demonstrated neuroprotective …

Traumatic brain injury (TBI) triggers a complex sequence of inflammatory responses that
contribute to secondary injury. Statins have demonstrated neuroprotective effects against …

The systemic administration of atorvastatin has been shown to be neuroprotective after
spinal cord injury (SCI), by decreasing the inflammatory response at the lesion site and by …

Traumatic brain injury (TBI) remains a major public health problem globally. Presently, there
is no way to restore cognitive deficits caused by TBI. In this study, we seek to evaluate the …

Statins administered postischemia promote functional improvement in rats, independent of
their capability to lower cholesterol. We therefore tested the effect of statin treatment on …

The beneficial effects of simvastatin on experimental traumatic brain injury (TBI) have been
demonstrated in previous studies. In this study, we investigated the effects of simvastatin on …

Traumatic brain injury (TBI) and intracerebral hemorrhage (ICH) are leading causes of
neurological mortality and disability in the US However, therapeutic options are limited and …