Small cell lung carcinoma (SCLC) is a fast-growing, highly metastatic form of lung cancer. A
major difference between SCLC and other forms of lung cancer is that SCLC tumors often …

Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …

Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …

Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …

Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …

Small cell lung carcinoma (SCLC) is a highly lethal, smoking-associated cancer with few
known targetable genetic alterations. Using genome sequencing, we characterized the …

Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …

Although a number of molecules have been implicated in the process of cancer metastasis,
the organ-selective nature of cancer cells is still poorly understood. To investigate this issue …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

Tumor heterogeneity can create a unique symbiotic tumor microenvironment. Earlier, we
showed that clonal evolution in mouse small cell lung cancer (SCLC) can result in …