Tumor heterogeneity can create a unique symbiotic tumor microenvironment. Earlier, we
showed that clonal evolution in mouse small cell lung cancer (SCLC) can result in …

Small cell lung carcinoma (SCLC) is a neuroendocrine subtype of lung cancer that affects
more than 200,000 people worldwide every year with a very high mortality rate. Here, we …

Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality.
Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy …

Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor
heterogeneity (ITH) associated with high recurrence rate and suboptimal response to …

The use of potent therapies inhibiting critical oncogenic pathways active in epithelial
cancers has led to multiple resistance mechanisms, including the development of highly …

Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has
metastasized. Despite the need to better understand this disease, SCLC remains poorly …

Small-cell lung cancer is the most aggressive type of lung cancer, characterized by a
remarkable response to chemotherapy followed by development of resistance. Here, we …

Substantial evidence supports the concept that cancers are organized in a cellular hierarchy
with cancer stem cells (CSC) at the apex. To date, the primary evidence for CSCs derives …

Over the past several years, we have witnessed a resurgence of interest in the biology and
therapeutic vulnerabilities of small-cell lung cancer (SCLC). This has been driven in part …

Cancer patients die primarily due to disease recurrence after transient treatment responses.
The emergence of therapy‐resistant escape variants is fuelled by intra‐tumour …