[HTML][HTML] Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
Small cell lung cancer (SCLC) is a highly malignant tumor which is eventually refractory to
any treatment. Intratumoral heterogeneity (ITH) may contribute to treatment failure. However …
any treatment. Intratumoral heterogeneity (ITH) may contribute to treatment failure. However …
Genetic and non-genetic clonal diversity in cancer evolution
JRM Black, N McGranahan - Nature Reviews Cancer, 2021 - nature.com
The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …
studies, has advanced our understanding of the evolutionary forces that shape cancer …
Cells of origin of lung cancers: lessons from mouse studies
As one of the most common forms of cancer, lung cancers present as a collection of different
histological subtypes. These subtypes are characterized by distinct sets of driver mutations …
histological subtypes. These subtypes are characterized by distinct sets of driver mutations …
[HTML][HTML] Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
Adopting a systems approach, we devise a general workflow to define actionable subtypes
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …
Cell plasticity and heterogeneity in cancer
ND Marjanovic, RA Weinberg, CL Chaffer - Clinical chemistry, 2013 - academic.oup.com
BACKGROUND Heterogeneity within a given cancer arises from diverse cell types recruited
to the tumor and from genetic and/or epigenetic differences amongst the cancer cells …
to the tumor and from genetic and/or epigenetic differences amongst the cancer cells …
Small cell lung cancer: will recent progress lead to improved outcomes?
Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy with a unique
natural history characterized by a short doubling time, high growth fraction, and early …
natural history characterized by a short doubling time, high growth fraction, and early …
Anchorage-independent cell growth signature identifies tumors with metastatic potential
The oncogenic phenotype is complex, resulting from the accumulation of multiple somatic
mutations that lead to the deregulation of growth regulatory and cell fate controlling activities …
mutations that lead to the deregulation of growth regulatory and cell fate controlling activities …
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
M Peifer, L Fernández-Cuesta, ML Sos, J George… - Nature …, 2012 - nature.com
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis,,.
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …
[HTML][HTML] Investigating tumor heterogeneity in mouse models
Cancer arises from a single cell through a series of acquired mutations and epigenetic
alterations. Tumors gradually develop into a complex tissue comprised of phenotypically …
alterations. Tumors gradually develop into a complex tissue comprised of phenotypically …
[HTML][HTML] Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer
The majority of small cell lung cancer (SCLC) patients demonstrate initial chemo-sensitivity,
whereas a distinct subgroup of SCLC patients, termed chemo-refractory, do not respond to …
whereas a distinct subgroup of SCLC patients, termed chemo-refractory, do not respond to …