Background Lineage plasticity, the ability to transdifferentiate among distinct phenotypic
identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs) …

Background The advent of rapid and inexpensive sequencing technology allows scientists
to decipher heterogeneity within primary tumours, between primary and metastatic sites, and …

Quantifying the genetic correlation between cancers can provide important insights into the
mechanisms driving cancer etiology. Using genome-wide association study summary …

With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …

As tumors accumulate genetic alterations, an evolutionary process occurs in which
genetically distinct subclonal populations of cells co-exist, resulting in intratumor genetic …

Advances in genomics in recent years have provided key insights into defining cancer
subtypes “within-a-tissue”—that is, respecting traditional anatomically driven divisions of …

Somatic rearrangements resulting in genomic structural variation drive malignant
phenotypes by altering the expression or function of cancer genes. Pan-cancer studies have …

The population of cells that make up a cancer are manifestly heterogeneous at the genetic,
epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra …

Intratumour heterogeneity (ITH) may foster tumour adaptation and compromise the efficacy
of personalized medicine approaches. The scale of heterogeneity within a tumour …

Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate
biologic mechanisms inherent in the normal cell state that have been co-opted to drive the …