Invasion of spheroids from 20 human primary glioblastomas into precultured fetal rat brain
tissue in culture has been studied and quantified. Between 30 and 98 percent of the normal …

Malignant human glioma is characterized by an uncontrolled cell proliferation and infiltrative
growth into the brain. The mechanisms by which invasion occurs are poorly understood …

The in vitro invasive growth of two continuous human glioma cell lines (D-54Mg and GaMg)
into aggregates of fetal rat brain cells is described. The tumor cells were first cultured as …

The invasiveness of human intracranial tumours was studied in an organ culture system.
Biopsies from six glioblastomas, four astrocytomas, two mixed gliomas, one ependymoma …

Two malignant rat neurogenic cell lines have been confronted with reaggregation cultures of
fetal rat brain in a stationary culture system. In this organ culture system several …

Since it is difficult to study the dynamic biological aspects of brain tumour invasion using
histological sections of surgical biopsy and autopsy tissues, various laboratory systems have …

Five established cell lines derived from human anaplastic astrocytomas or glioblastoma
multiforme were tested for invasiveness into precultured chick heart fragments in vitro. Four …

Gliomas exhibit diffuse infiltration into the normal brain parenchyma, and the tumor cells
often show morphological features similar to reactive glia cells, making it difficult to …

The mechanisms that control the insidiously invasive nature of malignant gliomas are poorly
understood, and their study would be facilitated by an in vivo model that is easy to …

Primary malignant neoplasms of the nervous system differ from other types of malignancy in
several ways. Clinical progression is due to local invasive growth, while metastases outside …