In striated muscles, contractility is controlled by Ca 2+ binding to the regulatory protein
complex troponin, which is a component of the thin filaments. Troponin is an allosteric …

Tropomyosin is in many ways the arche-typal coiled-coil fibrous protein and has played a
central role in developing an understanding of the function of this class of proteins in …

We have developed an in vitro motility assay to make a detailed quantitative analysis of
Ca2+ control of skeletal-muscle troponin-tropomyosin control of actin-filament movement …

The molecular regulation of striated muscle contraction couples the binding and dissociation
of Ca2+ on troponin (Tn) to the movement of tropomyosin on actin filaments. In turn, this …

The discovery of native tropomyosin, a calcium-sensitizing protein factor in the actin-myosin
interaction signalled the start of a new era in the molecular biology of muscle contractions …

The regulation of muscle contraction by the thin filament proteins tropomyosin (Tm) and
troponin (Tn) has remained an area of interest since the proteins were first discovered 40 …

Tropomyosin is a filamentous coiled-coil protein directly involved in the regulation of the
actomyosin interaction responsible for muscle contraction: it transmits the local calcium …

Sherwin S. Lehrer,** David R. Betteridge, Philip Graceffa, Sunny Wong, and John C. Seidel
abstract: In contrast toprevious conformational studies with rabbit skeletal and cardiac …

Striated muscle contraction is governed by the thin filament regulatory proteins troponin and
tropomyosin. Here, we investigate the molecular mechanisms by which troponin …

About 30 years ago the proceedings of the Cold Spring Harbor Symposium in Quantitative
Biology entitled 'The Mechanism of Muscle Contraction'was published. A key topic in that …