The search for new agents targeting different forms of cell death is an important research
focus for developing new and potent antitumor therapies. As a contribution to this endeavor …

A synthetic pathway to a novel 4-aryl-3, 4-dihydro-2 H-1, 4-benzoxazine scaffold was
developed and a series of compounds based on the scaffold were synthesised as potential …

Background: Cancer exerts a huge strain on the health system. The emerging resistance to
the current chemotherapies demands the continuous development of new anticancer agents …

Abstract Multi-target EGFR, HER2, VEGFR-2 and PDGFR is an improved strategy for the
treatment of solid tumors. This work deals with synthesis of an array of new 6-benzoyl …

In continuing efforts of improving benzoxazepine derivatives as an anti-breast cancer agent,
a new chemical entity, benzoxazine, was designed from scaffold morphing. Structure …

Abstract The synthesis of 6-aryl, 8-aryl, and 8-aryl-6-chloro-2-morpholino-1, 3-benzoxazines
with potent activity against PI3K and DNA-PK is described. Synthesis of thirty one analogues …

Angiogenesis is vital for solid tumor growth, and its prevention is a proven strategy for the
treatment of disease states such as cancer. The vascular endothelial growth factor (VEGF) …

Background: The genetic heterogeneity of tumor cells and the development of therapy-
resistant cancer cells in addition to the high cost necessitate the continuous development of …

Two series of new benzoxazepines substituted with different alkyl amino ethyl chains were
synthesized comprising synthetic steps of inter and intramolecular Mitsunobu reaction …

A new one pot three-component reaction for the synthesis of benzo [a] pyrano-[2, 3-c]
phenazine derivatives has been developed. The synthesis was achieved by reacting benzo …