Despite the continuous improvement of various therapeutic techniques, the overall
prognosis of tumors has been significantly improved, but malignant tumors in the middle and …

Solid tumour tissues contain a tumour microenvironment (TME) which influences tumour
progression and therapy resistance (Romano et al., 2021). TME is a network including …

The failure of malignant cells to undergo apoptosis is a major obstacle in cancer therapy,
and thus identifying the underlining molecules involved therein is imperative for improving …

Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …

The tumor microenvironment is often overlooked when considering tumor response to
chemotherapeutic agents. This environment consists of soluble factors, components of the …

Cellular adhesion molecules are critical components during carcinogenesis and cancer
metastasis and contribute to the mechanisms underlying resistance to chemotherapeutic …

Acquired drug resistance continues to be one of the major obstacles hindering the
successful treatment of many forms of cancer. Compounds utilized as antagonists of these …

The cell adhesion molecule CADM1, which participates in cell adhesion and signal
transduction, has a regulatory effect on the development of tumors. CADM1 is often involved …

The impact of cell adhesion in the pathobiology of tumors has been studied almost
exclusively in the context of invasion, angiogenesis, and metastasis. Here we review data …

Cell adhesion-mediated resistance limits the success of cancer therapies and is a great
obstacle to overcome in the clinic. Since the 1990s, where it became clear that adhesion of …