In vitro studies in bacterial, yeast and eukaryotic systems have demonstrated the existence
of deletion and insertion 'hotspots' involving repetitive sequences. Slipped-strand mispairing …

Short tandem repeats (STRs) are subjected to two kinds of mutational modifications: point
mutations and replication slippages. The latter is found to be the more frequent cause of …

Abstract A total of 20,000 parent-offspring transfers of alleles were examined through the
genotyping within 40 CEPH reference families of 28 short tandem repeat polymorphisms …

Short tandem repeat sequences in the mammalian genome are considered to be unstable,
since many of them are polymorphic ln length; however, the extent of this instability has …

We report a high rate of new mutation at a short tandem repeat sequence polymorphism
(STR, microsatellite) at locus DXS981 on the proximal long arm of the human X …

Simple sequence repeats are predominantly found in most organisms. They play a major
role in studies of genetic diversity, and are useful as diagnostic markers for many diseases …

Single nucleotide polymorphisms (SNPs) are widely distributed in the human genome and
although most SNPs are the result of independent point-mutations, there are exceptions …

Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly
understood. We examined these processes by introducing a two-phase mutation model. In …

This paper uses data from the Human Gene Mutation Database to contrast two hypotheses
for the origin of short DNA repeats: substitutions and insertions that duplicate adjacent …

In the human genome, short tandem repetitive (STR) DNA sequences often show restriction
fragment length polymorphisms (RFLPs) due to variation in the number of copies of the …