In this study we explored the potential role of the complement derived anaphylatoxin C5a
and the expression of its receptor in mouse brain. Using in situ hybridization, we found that …

Complement system activation within the central nervous system (CNS) is involved in
demyelinating and neurodegenerative disorders, but the role of complement in the …

Human astrocyte cell lines reportedly contain a specific receptor for the complement
anaphylatoxin C3a based on ligand‐binding studies, functional responses, and RNA …

There is now clear evidence that the Complement anaphylatoxin C3a and C5a receptors
(C3aR and C5aR) are expressed in glial cells, notably in astrocytes and microglia. In …

C3a and C5a anaphylatoxins are two proinflammatory peptides generated during
complement system activation. C3a and C5a exert several biological activities through …

Several studies suggest the involvement of the complement system in the pathophysiology
of traumatic brain injury (TBI). Since the intrathecal generation of anaphylatoxin C5a has …

C3a and C5a anaphylatoxins are two proinflammatory peptides generated during
complement activation that act through distinct Gi protein‐coupled receptors named C3aR …

The anaphylatoxin C5a is a potent mediator of inflammation in the CNS. We analyzed the
intracerebral expression of the C5a receptor (C5aR) in a model of closed head injury (CHI) …

There is evidence that the complement system, a major component of inflammatory
responses, may play an important role in neurodegenerative conditions such as Alzheimer's …

The present studies were undertaken to determine whether neuronal subsets in normal
brains constitutively express functionally competent C5a receptors. In situ hybridization …