Pifithrin‐α enhances the survival of transplanted neural stem cells in stroke rats by inhibiting p53 nuclear translocation
XH Lei, D Zhao, YL Li, XF Li, X Sun… - CNS neuroscience & …, 2013 - Wiley Online Library
Aims To examine a novel strategy to enhance the survival of grafted neural stem cells (NSC
s) in stroke model. Methods Using a cell counting kit‐8 (CCK‐8) and TUNEL assay to test …
s) in stroke model. Methods Using a cell counting kit‐8 (CCK‐8) and TUNEL assay to test …
Sequential combined treatment of pifithrin-α and Posiphen enhances neurogenesis and functional recovery after stroke
F Turcato, P Kim, A Barnett, Y Jin… - Cell …, 2018 - journals.sagepub.com
Objective: Although cerebral ischemia can activate endogenous reparative processes, such
as proliferation of endogenous neural stem cells (NSCs) in the subventricular zone (SVZ) …
as proliferation of endogenous neural stem cells (NSCs) in the subventricular zone (SVZ) …
[HTML][HTML] Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner
P Zhang, X Lei, Y Sun, H Zhang, L Chang, C Li, D Liu… - Scientific reports, 2016 - nature.com
Promoting regenerative repair, including neurogenesis and angiogenesis, may provide a
new therapeutic strategy for treatment of stroke. P53, a well-documented transcription factor …
new therapeutic strategy for treatment of stroke. P53, a well-documented transcription factor …
[HTML][HTML] TNF-α induces human neural progenitor cell survival after oxygen–glucose deprivation by activating the NF-κB pathway
M Kim, K Jung, IS Kim, IS Lee, Y Ko, JE Shin… - … & molecular medicine, 2018 - nature.com
Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the
ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic …
ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic …
[HTML][HTML] Transplantation of bFGF-expressing neural stem cells promotes cell migration and functional recovery in rat brain after transient ischemic stroke
JJ Zhang, JJ Zhu, YB Hu, GH Xiang, LC Deng, FZ Wu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cerebrovascular disease such as stroke is one of the most common diseases in the aging
population, and neural stem cells (NSCs) transplantation may provide an alternative therapy …
population, and neural stem cells (NSCs) transplantation may provide an alternative therapy …
PDGFR-beta signaling mediates endogenous neurogenesis after postischemic neural stem/progenitor cell transplantation in mice
J Shen, T Zhang, H Guan, X Li, S Zhang, G Xu - Brain Injury, 2023 - Taylor & Francis
Objective Although platelet-derived growth factor receptor (PDGFR)-β mediates the self-
renewal and multipotency of neural stem/progenitor cells (NSPCs) in vitro and in vivo, its …
renewal and multipotency of neural stem/progenitor cells (NSPCs) in vitro and in vivo, its …
Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia
Y Yao, R Zhou, R Bai, J Wang, M Tu, J Shi, X He… - Frontiers of …, 2021 - Springer
Hypoxia conditioning could increase the survival of transplanted neuronal progenitor cells
(NPCs) in rats with cerebral ischemia but could also hinder neuronal differentiation partly by …
(NPCs) in rats with cerebral ischemia but could also hinder neuronal differentiation partly by …
Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats
B Chen, XQ Gao, CX Yang, SK Tan, ZL Sun, NH Yan… - Brain research, 2009 - Elsevier
Previous studies indicated the beneficial effects of glial cell line-derived neurotrophic factor
(GDNF) and transplanted neural stem cells (NSCs) on stroke. Here, we explored whether …
(GDNF) and transplanted neural stem cells (NSCs) on stroke. Here, we explored whether …
Transplantation of neural stem cells overexpressing glial cell line-derived neurotrophic factor enhances Akt and Erk1/2 signaling and neurogenesis in rats after stroke
M Yuan, SJ Wen, C Yang, YG Pang, XQ Gao… - Chinese Medical …, 2013 - mednexus.org
Background Our previous studies have indicated that the beneficial effects of grafting neural
stem cells (NSCs) overexpressing glial cell line-derived neurotrophic factor (GDNF) in rats …
stem cells (NSCs) overexpressing glial cell line-derived neurotrophic factor (GDNF) in rats …
[HTML][HTML] TNF-α pretreatment improves the survival and function of transplanted human neural progenitor cells following hypoxic-ischemic brain injury
Neural progenitor cells (NPCs) therapy offers great promise in hypoxic-ischemic (HI) brain
injury. However, the poor survival of implanted NPCs in the HI host environment limits their …
injury. However, the poor survival of implanted NPCs in the HI host environment limits their …
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