[HTML][HTML] Severe COVID-19 and aging: are monocytes the key?
BD Pence - Geroscience, 2020 - Springer
The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by a high mortality of elderly men with age-related comorbidities. In most of these patients …
by a high mortality of elderly men with age-related comorbidities. In most of these patients …
[HTML][HTML] A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome …
A Bektas, SH Schurman, C Franceschi, L Ferrucci - Immunity & Ageing, 2020 - Springer
A central clinical question as the world deals with the COVID-19 pandemic is what the long-
term sequelae for the millions of individuals will be who recover from the hyperinflammatory …
term sequelae for the millions of individuals will be who recover from the hyperinflammatory …
A human circulating immune cell landscape in aging and COVID-19
Y Zheng, X Liu, W Le, L Xie, H Li, W Wen, S Wang… - Protein & …, 2020 - academic.oup.com
Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …
However, a global and detailed characterization of the changes that human circulating …
[HTML][HTML] Impaired immune response drives age-dependent severity of COVID-19
J Beer, S Crotta, A Breithaupt, A Ohnemus… - Journal of Experimental …, 2022 - rupress.org
Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19
EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …
[HTML][HTML] Can an effective SARS-CoV-2 vaccine be developed for the older population?
G Pawelec, N Weng - Immunity & Ageing, 2020 - Springer
The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe
challenges to the wellbeing of millions of people worldwide, health care systems and the …
challenges to the wellbeing of millions of people worldwide, health care systems and the …
[HTML][HTML] COVID-19 immunobiology: lessons learned, new questions arise
A Kaklamanos, K Belogiannis, P Skendros… - Frontiers in …, 2021 - frontiersin.org
There is strong evidence that COVID-19 pathophysiology is mainly driven by a
spatiotemporal immune deregulation. Both its phenotypic heterogeneity, spanning from …
spatiotemporal immune deregulation. Both its phenotypic heterogeneity, spanning from …
Immunosenescence and COVID-19
JM Witkowski, T Fulop, E Bryl - Mechanisms of ageing and development, 2022 - Elsevier
Ageing is associated with modified function of both innate and adaptive immunity. It is
believed that changes occurring in ageing immune system are responsible for increased …
believed that changes occurring in ageing immune system are responsible for increased …