[HTML][HTML] Immunosenescence and altered vaccine efficiency in older subjects: A myth difficult to change
Organismal ageing is associated with many physiological changes, including differences in
the immune system of most animals. These differences are often considered to be a key …
the immune system of most animals. These differences are often considered to be a key …
[HTML][HTML] Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults
MÁ Palacios-Pedrero, JM Jansen, C Blume… - Nature Aging, 2022 - nature.com
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
effective in preventing COVID-19 hospitalization and fatal outcome. However, several …
effective in preventing COVID-19 hospitalization and fatal outcome. However, several …
Cytokine response in SARS-CoV-2 infection in the elderly
S Sherwani, MWA Khan - Journal of Inflammation Research, 2020 - Taylor & Francis
The last few months of 2019 witnessed the emergence, rise and rapid spread of a novel
coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
[HTML][HTML] The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1
R Kandhaya‐Pillai, X Yang, T Tchkonia, GM Martin… - Aging cell, 2022 - Wiley Online Library
Older age and underlying conditions such as diabetes/obesity or immunosuppression are
leading host risk factors for developing severe complications from COVID‐19 infection. The …
leading host risk factors for developing severe complications from COVID‐19 infection. The …
[HTML][HTML] Markers of T cell senescence in humans
Many countries are facing the aging of their population, and many more will face a similar
obstacle in the near future, which could be a burden to many healthcare systems. Increased …
obstacle in the near future, which could be a burden to many healthcare systems. Increased …
[HTML][HTML] Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients
A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity
has come out as a determinant for COVID-19 clinical outcomes, and several studies …
has come out as a determinant for COVID-19 clinical outcomes, and several studies …
[HTML][HTML] How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity
A Smorenberg, EJG Peters, PLA van Daele… - European Journal of …, 2021 - Elsevier
Abstract Importance: Among COVID-19 cases, especially the (frail) elderly show a high
number of severe infections, hospital admissions, complications, and death. The highest …
number of severe infections, hospital admissions, complications, and death. The highest …
The immunology of long COVID
DM Altmann, EM Whettlock, S Liu… - Nature Reviews …, 2023 - nature.com
Long COVID is the patient-coined term for the disease entity whereby persistent symptoms
ensue in a significant proportion of those who have had COVID-19, whether asymptomatic …
ensue in a significant proportion of those who have had COVID-19, whether asymptomatic …
[HTML][HTML] Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy
Abstract Background In December 2019, a novel human-infecting coronavirus, SARS-CoV-
2, had emerged. The WHO has classified the epidemic as a “public health emergency of …
2, had emerged. The WHO has classified the epidemic as a “public health emergency of …