Pharmacogenetic basis for therapeutic optimization in Alzheimer's disease
R Cacabelos - Molecular diagnosis & therapy, 2007 - Springer
Alzheimer's disease is a major health problem in developed countries. Approximately 10–
15% of direct costs in dementia are attributed to pharmacological treatment, and only 10 …
15% of direct costs in dementia are attributed to pharmacological treatment, and only 10 …
High‐dose donepezil (23 mg/day) for the treatment of moderate and severe Alzheimer's disease: drug profile and clinical guidelines
JL Cummings, D Geldmacher, M Farlow… - CNS neuroscience & …, 2013 - Wiley Online Library
To provide healthcare professionals with a comprehensive assessment of donepezil 23 mg
and its role in treating A lzheimer's disease (AD), the Donepezil 23 mg Expert Working …
and its role in treating A lzheimer's disease (AD), the Donepezil 23 mg Expert Working …
Pharmacogenetics in medicine: barriers, critical factors and a framework for dialogue
I Zineh, LJ Lesko - Personalized Medicine, 2009 - Future Medicine
drugs to be used in patients. Randomized, con trolled trials (RCTs), prospective outcomes
stud ies and comparative effectiveness studies are likely to be resource prohibitive in the …
stud ies and comparative effectiveness studies are likely to be resource prohibitive in the …
Clinical pharmacogenomics: applications in pharmaceutical R&D
RM Norton - Drug discovery today, 2001 - Elsevier
Within the pharmaceutical industry, the application of clinical pharmacogenomics promises
to enhance the discovery of drug response markers, reduce the size and expense of clinical …
to enhance the discovery of drug response markers, reduce the size and expense of clinical …
Pharmacogenomics, a novel section in the European Journal of Human Genetics
HJ Guchelaar - European Journal of Human Genetics, 2018 - nature.com
Now 15 years ago, in 2003, the International Human Genome Sequencing Consortium
proudly announced that the Human Genome Project had been completed. This endeavor …
proudly announced that the Human Genome Project had been completed. This endeavor …
Pharmacogenetics of antidepressant drugs: an update after almost 20 years of research
C Fabbri, G Di Girolamo… - American Journal of …, 2013 - Wiley Online Library
Major depressive disorder (MDD) is an emergent cause of personal and socio‐economic
burden, both for the high prevalence of the disorder and the unsatisfying response rate of …
burden, both for the high prevalence of the disorder and the unsatisfying response rate of …
Current pharmacogenomic approaches to clinical drug development
MP Murphy - Pharmacogenomics, 2000 - Future Medicine
Pharmacogenomics has recently become an integral part of the drug development process.
The pharmacogenomics revolution comes at a time when pharmaceutical companies are …
The pharmacogenomics revolution comes at a time when pharmaceutical companies are …
[HTML][HTML] Role of pharmacogenomic biomarkers in predicting and improving drug response: part 1: the clinical significance of pharmacogenetic variants
CL Ventola - Pharmacy and Therapeutics, 2013 - ncbi.nlm.nih.gov
Role of Pharmacogenomic Biomarkers In Predicting and Improving Drug Response - PMC Back
to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage …
to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage …
Pharmacogenomics: Genetic polymorphisms
NM Varela, LC Cerpa, MM Martínez… - The ADME Encyclopedia …, 2021 - Springer
Background It has been estimated that the human genome harbors about 30,000 protein-
coding genes. Within these proteins we find transporters, metabolizing enzymes, and …
coding genes. Within these proteins we find transporters, metabolizing enzymes, and …
Effects of vitamin D receptor, cytochrome P450 3A, and cytochrome P450 oxidoreductase genetic polymorphisms on the pharmacokinetics of remimazolam in healthy …
K Hu, Q Xiang, Z Wang, X Sheng, L Li… - Clinical …, 2021 - Wiley Online Library
Remimazolam is a new ultra‐short‐acting benzodiazepine used to induce and maintain
anesthesia and procedural sedation. Its compound structure is similar to midazolam's …
anesthesia and procedural sedation. Its compound structure is similar to midazolam's …