P-glycoprotein (P-gp) is a transmembrane transporter playing an important role in drug
efflux. There is growing evidence that P-gp activity may be related to haplotypes of MDR1 …

There exists a marked inter-individual variability of P-glycoprotein expression and activity,
which can be of clinical importance due to the large number of drugs that are substrates for …

P-glycoprotein (P-gp), the protein product of MDR1 gene, is an important factor regulating
the bioavailability of many therapeutics. Recently, the C3435T polymorphism of MDR1 was …

The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as
a gate-keeper against various kinds of xenobiotics. Several single nucleotide …

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on
chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide …

In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

OBJECTIVES: P-glycoprotein (P-gp) is significant from the viewpoint of pharmacokinetics/
pharmacodynamics (PK/PD). MDR1 gene encodes P-gp and has a wide variety of SNPs. As …

Background P‐glycoprotein, the gene product of MDR1, confers multidrug resistance
against antineoplastic agents but also plays an important role in the bioavailability of …

Sumamry Background: P‐glycoprotein (PgP) is the most extensively studied ATP‐binding
cassette (ABC) coded by MDR1 gene. To date, 29 single nucleotide polymorphisms (SNPs) …

P-glycoprotein (PGP) is a transmembrane efflux transporter with an important role in drug
therapy. The level of PGP expression leads to relevant consequences in terms of efficacy …