How axons repair themselves after injury is a fundamental question in neurobiology. With its
conserved genome, relatively simple nervous system, and transparent body, C. elegans has …

Axon regeneration is a medically relevant process that can repair damaged neurons. This
review describes current progress in understanding axon regeneration in the model …

Highlights•Genetic screening reveals relevant molecules and expands molecular landscape
of axon regeneration.•In-depth mechanistic dissection uncovers signaling pathways.•In vivo …

Understanding the mechanisms of axon regeneration is of great importance to the
development of therapeutic treatments for spinal cord injury or stroke. Axon regeneration …

Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual
green fluorescent protein‐labeled axons can be severed using laser microsurgery and their …

Highlights•The nematode Caenorhabditis elegans has recently emerged as a genetic model
for studying regenerative responses in neurons.•Axon regeneration is regulated by a …

Research into conditions that improve axon regeneration has the potential to open a new
door for treatment of brain injury caused by stroke and neurodegenerative diseases of …

Functional neuronal recovery following injury arises when severed axons reconnect with
their targets. In Caenorhabditis elegans following laser‐induced axotomy, the axon still …

The molecular and cellular mechanisms that allow adult-stage neurons to regenerate
following damage are poorly understood. Recently, axons of motoneurons and …

Axon regeneration has long been studied in vertebrate model organisms and neuronal
cultures. Recent development of axon regeneration paradigms in genetic model organisms …