Solid organ transplantation is the only treatment for end-stage organ failure but this life-
saving procedure is limited by immune-mediated rejection of most grafts. Blood vessels …

Allograft vasculopathy is an accelerated intimal hyperplastic lesion leading to progressive
vascular stenosis; it represents the major long-term limitation to successful solid organ …

Graft rejection remains the major obstacle after vascularized solid organ transplantation.
Endothelial cells, which form the interface between the transplanted graft and the host's …

Graft vascular disease (GVD) is the single most important long-term limitation to solid-organ
transplantation. It is a concentric vascular intimal hyperplastic lesion composed of smooth …

Rationale: Transplant arteriosclerosis is the major limitation to long-term survival of solid
organ transplantation. Although both immune and nonimmune cells have been suggested to …

Graft vasculopathy is an accelerated form of coronary artery disease that occurs in
transplanted hearts. Despite major advances in immunosuppression, the prevalence of the …

Allograft arteriopathy is a vascular intimal proliferative process that occurs in all solid organ
transplants and stands as the single most significant obstacle to successful long-term solid …

Human vascularized allografts are perfused through blood vessels composed of cells
(endothelium, pericytes, and smooth muscle cells) that remain largely of graft origin and are …

Cardiac allograft vasculopathy (CAV) is a pathologic immune-mediated remodelling of the
vasculature in transplanted hearts and, by impairing perfusion, is the major cause of late …

Advances in immunosuppression have decreased the incidence of acute rejection, but the
development of vasculopathy in the coronary arteries of transplants continues to limit the …