The vascular endothelium synthesizes and releases a spectrum of vasoactive substances
like nitric oxide (NO) and endothelin (ET). In hypertension, the delicate balance of …

The vascular endothelium plays a fundamental role in the basal and dynamic regulation of
the circulation. Thus, it has a crucial role in the pathogenesis of hypertension. A spectrum of …

Far from simply lining the inner surface of blood vessels, the cellular monolayer that
comprises the endothelium is a highly active organ that regulates vascular tone. In health …

Endothelium can deeply influence vascular tone and structure. The main endothelium-
derived factor is nitric oxide (NO), which not only is a potent vasodilator but also inhibits …

Oxidative stress contributes to homeostasis in vascular cells. However, excessive ROS is
pathophysiological and contributes to impaired endothelium-dependent dilation in …

In normotension the endothelium produces mainly nitric oxide (NO) and prostacyclin, and
the vasodilator and growth inhibitory influence predominates. Hypertension, however, is …

Vascular endothelial cells play a key role in cardiovascular regulation by producing a
number of potent vasoactive agents, including the vasodilator molecule nitric oxide (NO) and …

Endothelium-derived nitric oxide is not only a potent vasodilator but also inhibits platelet
aggregation, smooth muscle cell proliferation, monocyte adhesion and adhesion molecule …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …