The angiotensin AT2-receptor mediates tissue protective actions. Its regenerative potential
has been tested in multiple disease models including models of myocardial infarction. These …

There are strong data favoring the pathogenic role of angiotensin II type 1 receptor (AT1)
activation with subsequent promotion of myocyte growth and cardiac fibrosis in the …

Background—We have previously shown that the acute molecular growth response of new
protein synthesis and protein kinase C activation in response to angiotensin II (Ang II) is …

Aims Sustained hypertension leads to cardiac hypertrophy that can progress, through
pathological remodelling, to heart failure. Abnormality of the renin–angiotensin system …

Left ventricular hypertrophy (LVH) is considered to be an independent risk factor giving rise
to ischemia, arrhythmia, and left ventricular dysfunction. In this article, we summarize recent …

It is widely accepted that the angiotensin II type 1 receptor (AT1R) accounts for the majority
of cardiovascular effects evoked by angiotensin II (Ang II), such as contraction/pressor …

Left ventricular hypertrophy (LVH) associated with hy-pertension puts patients at heightened
risk for further cardiovascular complications. There has been lot of interest in the effects of …

Tsukuba hypertensive mice, which carry the human genes for renin and angiotensinogen,
show cardiac hypertrophy as well as hypertension due to activation of the renin-angiotensin …

The renin-angiotensin system (RAS) is intricately involved in cardiovascular homeostasis. It
is well known that angiotensin II, the key effector in RAS, contributes to a range of …

Angiotensin (Ang) II has two major receptor isoforms, AT1 and AT2. Currently, AT1
antagonists are undergoing clinical trials in patients with cardiovascular diseases. Treatment …