In Ghana, uncomplicated malaria and sickle cell disease (SCD) is common, hence
comorbidity is not farfetched. However, the extent of oxidative stress and the array of clinical …

Background Oxidative stress plays a vital role in the pathogenesis of both Sickle Cell
Disease (SCD) and Plasmodium falciparum malaria. However, there are limited studies on …

Background Intravascular hemolysis is an intrinsic feature of severe malaria
pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress …

Background: Oxidative stress, the imbalance between the productive of reactive species and
antioxidant defences notably plays an important role in the pathogenesis of sickle cell …

Malaria is a highly inflammatory and oxidative disease. The production of reactive oxygen
species by host phagocytes is an essential component of the host response to Plasmodium …

Introduction. Malaria is a leading cause of mortality among children below 5 years in Ghana.
Its parasites are known to cause the degradation of hemoglobin, resulting in the production …

Sickle cell disease (SCD) affects two-thirds of African and Indian children. Understanding
the molecular mechanisms contributing to oxidative stress may be useful for therapeutic …

Background Liver injury is a known feature of severe malaria, but is only incidentally
investigated in uncomplicated disease. In such cases, drug-induced hepatotoxicity is often …

Background Although loss of splenic function is the expected natural course for individuals
with sickle cell disease (SCD), factors such as high HbF and coexistence of alpha …

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …