Previous analysis of next‐generation sequencing (NGS) hereditary pan‐cancer panel
testing demonstrated that approximately 40% of TP53 pathogenic and likely pathogenic …

Li–Fraumeni syndrome (LFS) is an autosomal‐dominant cancer predisposition disorder
associated with pathogenic germline variants in TP53, with a high penetrance over an …

PURPOSE Multigene panel testing (MGPT) identifies TP53 pathogenic or likely pathogenic
(P/LP) variants in patients with diverse phenotypes, of which only one is classic Li-Fraumeni …

Pathogenic or likely pathogenic (P/LP) germline TP53 variants are the primary cause of Li-
Fraumeni syndrome (LFS), a hereditary cancer predisposition disorder characterized by …

Reports of variable cancer penetrance in Li–Fraumeni syndrome (LFS) have raised
questions regarding the prevalence of pathogenic germline TP53 variants. We previously …

Heterozygous (HET) TP53 pathogenic variants (PVs) are associated with Li-Fraumeni
syndrome (LFS), a dominantly inherited condition causing high risk for sarcoma, breast, and …

Introduction TP53 mutation carrier (Li-Fraumeni Syndrome, LFS) cohort studies often suffer
from lack of extensive pedigree exploration. Methods We performed a nation-wide …

Germline pathogenic variants in TP53 gene have different consequences according to cell,
tissue, context and age. The occurrence of frequent variants in patients with no criteria …

Germline pathogenic variants in TP53 are associated with Li‐Fraumeni syndrome, a cancer
predisposition disorder inherited in an autosomal dominant pattern associated with a high …

Summary Background Li-Fraumeni syndrome, caused primarily by pathogenic or likely
pathogenic germline TP53 variants, is a rare, variably penetrant, cancer predisposition …