Asthma is a common comorbidity in sickle cell disease (SCD) with a reported prevalence of
30–70%. The high frequency of asthma in this population cannot be attributed to genetic …

In recent years, evidence has increased that asthma predisposes to complications of sickle
cell disease (SCD), such as pain crises, acute chest syndrome, pulmonary hypertension …

Children with sickle cell disease (SCD) and a comorbid condition of asthma have increased
numbers of vaso-occlusive pain and acute chest syndrome episodes, and all-cause …

Prior studies of asthma in children with sickle cell disease (SCD) were based on reports of a
doctor‐diagnosis of asthma with limited description of asthma features. Doctor‐diagnoses of …

Sickle cell disease (SCD), the most common genetic hemolytic anemia worldwide, affects
250,000 births annually. In the United States, SCD affects approximately 100,000 …

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and
encompass acute and chronic disease. The understanding of the natural history of …

Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine,
the substrate for NO synthesis, is diminished. Impaired NO bioavailability represents the …

To assess the associations between a doctor diagnosis of asthma and wheezing
(independent of a diagnosis of asthma) with sickle cell disease (SCD) morbidity, we …

Despite a long history of knowing the genetic cause of sickle cell disease (SCD), progress in
developing treatments to prevent painful vaso-occlusive crises and the other myriad of …

Sickle cell disease (SCD) is the most common life-limiting genetic disease among African
Americans, affecting more than 100,000 people in the United States. Respiratory disorders …