Background: A proportion of people with treatment-resistant schizophrenia fail to show
improvement on clozapine treatment. Knowledge of the sociodemographic and clinical …

Importance Recent meta-analyses of randomized clinical trials (RCTs) comparing clozapine
with nonclozapine second-generation antipsychotics (NC-SGAs) in schizophrenia have …

BackgroundAlthough clozapine is the 'gold standard'for treatment-refractory schizophrenia,
meta-analyses of clozapine for this condition are lacking. AimsWe conducted a systematic …

Introduction: Treatment resistance in schizophrenia often leads to add-on of atypical
antipsychotics to clozapine. Methods: In a randomized trial, we recently obtained evidence …

Background Clozapine is the treatment of choice for medication refractory psychosis, but it
does not benefit half of those put on it. There are numerous studies of potential post …

Background Although clozapine is effective for treatment-resistant schizophrenia (TRS), the
rate of clozapine prescription is still low. Whereas antipsychotic monotherapy is …

Objective The aim of this systematic review and meta-analysis was to characterize ultra-
treatment-resistant Schizophrenia also known as clozapine-resistant schizophrenia (CRS) …

IntroductionClozapine is considered the gold standard for the treatment of patients with
treatment-resistant schizophrenia (TRS); however, randomized controlled trials (RCT) of …

According to surveys conducted in ten provinces and independent municipalities in China,
clozapine is the most commonly used antipsychotic medication in the country. These …

Although clozapine is more effective than other antipsychotics in the treatment of
schizophrenia, the rate of its discontinuation is also high. The aim of this retrospective chart …