The p38 MAP kinase pathway and its biological function
L New, J Han - Trends in cardiovascular medicine, 1998 - Elsevier
p38 is a mitogen-activated protein (MAP) kinase with structural and functional characteristics
that distinguish it from JNK and ERK MAP kinases. p38 activity is upregulated when cells are …
that distinguish it from JNK and ERK MAP kinases. p38 activity is upregulated when cells are …
p38 MAP kinases in the heart
T Yokota, Y Wang - Gene, 2016 - Elsevier
Abstract p38 kinases are members of the mitogen-activated protein kinases (MAPK) with
established contribution to a wide range of signaling pathways and different biological …
established contribution to a wide range of signaling pathways and different biological …
[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases
A Cuenda, S Rousseau - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …
of cellular stresses as well as in response to inflammatory cytokines. There are four …
p38 MAPK pathway in the heart: new insights in health and disease
R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …
p38 function has been studied in depth in relation to cardiac development and function. The …
[HTML][HTML] An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …
The p38 signal transduction pathway activation and function
The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …
pathway, plays an essential role in regulating many cellular processes including …
Effect of pressure overload-induced hypertrophy on the expression and localization of p38 MAP kinase isoforms in the mouse heart
D Dingar, C Merlen, S Grandy, MA Gillis… - Cellular signalling, 2010 - Elsevier
p38 mitogen-activated protein kinases (MAPKs) are serine/threonine specific protein
kinases that respond to cellular stress and regulate a broad range of cellular activities. There …
kinases that respond to cellular stress and regulate a broad range of cellular activities. There …
New insights into the p38γ and p38δ MAPK pathways
A Risco, A Cuenda - Journal of signal transduction, 2012 - Wiley Online Library
The mammalian p38 mitogen‐activated protein kinases (MAPKs) family is composed of four
members (p38α, p38β, p38γ, and p38δ), which are very similar in amino acid sequence but …
members (p38α, p38β, p38γ, and p38δ), which are very similar in amino acid sequence but …
Identification of cell cycle regulatory and inflammatory genes as predominant targets of p38 mitogen-activated protein kinase in the heart
O Tenhunen, J Rysä, M Ilves, Y Soini… - Circulation …, 2006 - Am Heart Assoc
Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in
response to extracellular stimulation, but the downstream effectors that mediate their …
response to extracellular stimulation, but the downstream effectors that mediate their …
Platelet-specific p38α deficiency improved cardiac function after myocardial infarction in mice
P Shi, L Zhang, M Zhang, W Yang, K Wang… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—MAPKs (mitogen-activated protein kinases), especially p38, play detrimental
roles in cardiac diseases and cardiac remodeling post-myocardial infarction. However, the …
roles in cardiac diseases and cardiac remodeling post-myocardial infarction. However, the …