The p38 MAP kinase pathway and its biological function

L New, J Han - Trends in cardiovascular medicine, 1998 - Elsevier
p38 is a mitogen-activated protein (MAP) kinase with structural and functional characteristics
that distinguish it from JNK and ERK MAP kinases. p38 activity is upregulated when cells are …

p38 MAP kinases in the heart

T Yokota, Y Wang - Gene, 2016 - Elsevier
Abstract p38 kinases are members of the mitogen-activated protein kinases (MAPK) with
established contribution to a wide range of signaling pathways and different biological …

[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases

A Cuenda, S Rousseau - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …

[HTML][HTML] p38 MAPK pathway in the heart: new insights in health and disease

R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …

[HTML][HTML] An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

J Han, J Wu, J Silke - F1000Research, 2020 - ncbi.nlm.nih.gov
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

The p38 signal transduction pathway activation and function

K Ono, J Han - Cellular signalling, 2000 - Elsevier
The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …

[HTML][HTML] Activation and signaling of the p38 MAP kinase pathway

T Zarubin, J Han - Cell research, 2005 - nature.com
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety
of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups …

Effect of pressure overload-induced hypertrophy on the expression and localization of p38 MAP kinase isoforms in the mouse heart

D Dingar, C Merlen, S Grandy, MA Gillis… - Cellular signalling, 2010 - Elsevier
p38 mitogen-activated protein kinases (MAPKs) are serine/threonine specific protein
kinases that respond to cellular stress and regulate a broad range of cellular activities. There …

New insights into the p38γ and p38δ MAPK pathways

A Risco, A Cuenda - Journal of signal transduction, 2012 - Wiley Online Library
The mammalian p38 mitogen‐activated protein kinases (MAPKs) family is composed of four
members (p38α, p38β, p38γ, and p38δ), which are very similar in amino acid sequence but …

Identification of cell cycle regulatory and inflammatory genes as predominant targets of p38 mitogen-activated protein kinase in the heart

O Tenhunen, J Rysä, M Ilves, Y Soini… - Circulation …, 2006 - Am Heart Assoc
Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in
response to extracellular stimulation, but the downstream effectors that mediate their …