Background Right ventricle failure (RVF) is a progressive heart disease that has yet to be
fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) …

Previous studies have highlighted the protective effects of pyruvate kinase M2 (PKM2)
overexpression in septic cardiomyopathy. In our study, we utilized cardiomyocyte-specific …

The endogenous mitochondrial quality control (MQC) system serves to protect mitochondria
against cellular stressors. Although mitochondrial dysfunction contributes to cardiac damage …

Rescuing cells from stress damage emerges a potential therapeutic strategy to combat
myocardial infarction. Protocatechuic aldehyde (PCA) is a major phenolic acid in Chinese …

Background Heart failure, caused by sustained pressure overload, remains a major public
health problem. PKM (pyruvate kinase M) acts as a rate‐limiting enzyme of glycolysis. PKM2 …

Adult animals are unable to regenerate heart cells due to postnatal cardiomyocyte cycle
arrest, leading to higher mortality rates in cardiomyopathy. However, reprogramming of …

Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that translocates to the nucleus to
regulate transcription factors in different tissues or pathologic states. Although studied …

M2-type pyruvate kinase (PKM2) contributes to the Warburg effect. However, it remains
unknown as to whether PKM2 has an inhibitory effect on mitochondrial function. We report in …

Context: Cardiomyocyte necrosis following myocardial infarction drastically the progression
of heart failure. Objective: In the current study, we explored the upstream mediator for …

The M2 isoform of pyruvate kinase (PKM2) is one isoform of pyruvate kinase (PK). PKM2 is
expressed at high levels during embryonic development and tumor progression and is …