[HTML][HTML] Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse …

YY Ma, HW Chen, CR Tzeng - Journal of ovarian research, 2017 - Springer
Background In human IVF, embryos cultured with a lower O 2 tension (5%) can give rise to
higher success rates when compared with normoxic conditions (20%). However, the …

Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model

WFA Marei, L Van den Bosch, I Pintelon… - Human …, 2019 - academic.oup.com
STUDY QUESTION Can we use a mitochondrial-targeted antioxidant (Mitoquinone) during
in vitro embryo culture to rescue developmental competence of oocytes matured under …

[HTML][HTML] L-carnitine decreases DNA damage and improves the in vitro blastocyst development rate in mouse embryos

H Abdelrazik, R Sharma, R Mahfouz, A Agarwal - Fertility and sterility, 2009 - Elsevier
OBJECTIVE: To optimize the L-carnitine (LC) concentration as a supplement in embryo
culture medium and to investigate the effect of LC on developing embryos. DESIGN …

Addition of glutathione or thioredoxin to culture medium reduces intracellular redox status of porcine IVM/IVF embryos, resulting in improved development to the …

M Ozawa, T Nagai, M Fahrudin… - Molecular …, 2006 - Wiley Online Library
The present series of experiments investigated the effect of a reducing environment created
by addition of reduced glutathione (GSH) or thioredoxin (TRX) to in vitro culture medium on …

Growth factors protect in vitro cultured embryos from the consequences of oxidative stress

R Kurzawa, W Glabowski, T Baczkowski… - Zygote, 2004 - cambridge.org
The aim of the study was to evaluate the effect of insulin-like growth factors (IGF1 and IGF2),
stem cell factor (SCF) and epidermal growth factor (EGF) on the development of embryos …

[HTML][HTML] Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

MLM Hardy, ML Day, MB Morris - International Journal of Environmental …, 2021 - mdpi.com
Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

[HTML][HTML] Importance of antioxidant supplementation during in vitro maturation of mammalian oocytes

SI Rakha, MA Elmetwally, H El-Sheikh Ali… - Veterinary …, 2022 - mdpi.com
Simple Summary In vitro embryo production (IVEP) is a technology that is widely used in the
field of reproductive biology. The first and most important step of IVEP is termed in vitro …

Reactive oxygen species in reproduction: harmful, essential or both?

M Jamil, H Debbarh, S Aboulmaouahib, OA Filali… - Zygote, 2020 - cambridge.org
The process of embryonic development is crucial and radically influences preimplantation
embryo competence. It involves oocyte maturation, fertilization, cell division and blastulation …

Culture of in vitro-produced bovine embryos with vitamin E improves development in vitro and after transfer to recipients

SE Olson, GE Seidel Jr - Biology of reproduction, 2000 - academic.oup.com
Detrimental effects of oxygen-derived free radicals on embryos during culture have been
demonstrated in several species. Vitamin E occurs naturally in cell membranes and protects …

Effects of oxygen concentration and antioxidants on the in vitro developmental ability, production of reactive oxygen species (ROS), and DNA fragmentation in porcine …

Y Kitagawa, K Suzuki, A Yoneda, T Watanabe - Theriogenology, 2004 - Elsevier
After in vitro maturation and fertilization of porcine oocytes, the fertilized embryos were
cultured under 5 or 20% oxygen (O2) for 7 days. In embryos cultured under 5% O2 versus …