Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response
Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - Journal of …, 2021 - Springer
Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which
has been demonstrated to have neuroprotective effects in different neurological disease …
has been demonstrated to have neuroprotective effects in different neurological disease …
Administration of tauroursodeoxycholic acid attenuates early brain injury via Akt pathway activation
D Sun, G Gu, J Wang, Y Chai, Y Fan, M Yang… - Frontiers in cellular …, 2017 - frontiersin.org
Traumatic brain injury (TBI) is one of the leading causes of trauma-induced mortality and
disability, and emerging studies have shown that endoplasmic reticulum (ER) stress plays …
disability, and emerging studies have shown that endoplasmic reticulum (ER) stress plays …
Ursodeoxycholic acid inhibits inflammatory responses and promotes functional recovery after spinal cord injury in rats
The aim of this study was to investigate the anti-inflammatory effects by ursodeoxycholic acid
(UDCA) in rats with a spinal cord injury (SCI). A moderate mechanical compression injury …
(UDCA) in rats with a spinal cord injury (SCI). A moderate mechanical compression injury …
Application of tauroursodeoxycholic acid for treatment of neurological and non-neurological diseases: is there a potential for treating traumatic brain injury?
KR Gronbeck, CMP Rodrigues, J Mahmoudi… - Neurocritical care, 2016 - Springer
The objective of this review was to evaluate the potential of tauroursodeoxycholic acid
(TUDCA) for neuroprotection in traumatic brain injury (TBI) patients in the neurocritical care …
(TUDCA) for neuroprotection in traumatic brain injury (TBI) patients in the neurocritical care …
Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation
N Yanguas-Casás, MA Barreda-Manso… - Journal of …, 2014 - Springer
Background Bile acids are steroid acids found predominantly in the bile of mammals. The
bile acid conjugate tauroursodeoxycholic acid (TUDCA) is a neuroprotective agent in …
bile acid conjugate tauroursodeoxycholic acid (TUDCA) is a neuroprotective agent in …
Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats
A Çolak, B Kelten, A Sağmanligil, O Akdemir… - Journal of Clinical …, 2008 - Elsevier
Greater clinical understanding of the pivotal role of apoptosis in spinal cord injury (SCI) has
led to new and innovative apoptosis-based therapies for patients with an SCI …
led to new and innovative apoptosis-based therapies for patients with an SCI …
Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury
This study aimed to investigate the anti-inflammatory effects of tauroursodeoxycholic acid
(TUDCA) after spinal cord injury (SCI) in rats. We induced an inflammatory process in RAW …
(TUDCA) after spinal cord injury (SCI) in rats. We induced an inflammatory process in RAW …
Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice
Accumulating evidence has shown that tauroursodeoxycholic acid (TUDCA) is
neuroprotective in different animal models of neurological diseases. However, whether …
neuroprotective in different animal models of neurological diseases. However, whether …
Injectable hydrogel containing tauroursodeoxycholic acid for anti-neuroinflammatory therapy after spinal cord injury in rats
We investigate the anti-inflammatory effects of injectable hydrogel containing
tauroursodeoxycholic acid (TUDCA) in a spinal cord injury (SCI) model. To this end, TUDCA …
tauroursodeoxycholic acid (TUDCA) in a spinal cord injury (SCI) model. To this end, TUDCA …
Tauroursodeoxycholic acid ameliorates lipopolysaccharide-induced depression like behavior in mice via the inhibition of neuroinflammation and oxido-nitrosative …
L Cheng, C Huang, Z Chen - Pharmacology, 2019 - karger.com
Depression is a mental disease that causes severe economic and social burdens. The
mechanism for the onset of depression remains largely unknown. Recently, more and more …
mechanism for the onset of depression remains largely unknown. Recently, more and more …
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