Following the initial acute stage of spinal cord injury, a cascade of cellular and inflammatory
responses will lead to progressive secondary damage of the nerve tissue surrounding the …

Background Traumatic spinal cord injury (SCI) is damage to the spinal cord that results in
damaged spinal cord function. As a natural compound, curcumin has recently been shown …

Spinal cord injury (SCI) leads to an inflammatory response that generates substantial
secondary damage within the tissue besides the primary damage. Leukotrienes are …

Abstract Objectives: 4-N-trimethylammonium-3-hydroxybutyric acid (L-carnitine) is an
endogenous mitochondrial membrane compound and some studies have reported that L …

Background Microglial polarization with M1/M2 phenotype shifts and the subsequent
neuroinflammatory responses are vital contributing factors for spinal cord injury (SCI) …

Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol
found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin …

BACKGROUND: Oxidative and inflammatory damages have been suggested to play an
important role in cerebral ischemic pathogenesis, and provide promising therapeutic …

Spinal cord injury (SCI) is a major cause of irreversible nerve injury and leads to serious
tissue loss and neurological dysfunction. Thorough investigation of cellular mechanisms …

Neuronal autophagy and inflammatory responses are important in the pathogenesis of
traumatic brain injury (TBI), and toll-like receptor 4 (TLR4) may play an important role in the …

High levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy), contribute to
autophagy and ischemia/reperfusion injury (I/R). Previous studies have shown that I/R injury …