The documentation from precursors of modern medicine had noted that pain and its
therapies have been present for centuries and millennia [1]. Charles Darwin described pain …

Neuropathic pain is part of the neurological disease spectrum and may be an expression of
severe medical pathology. Painful neuropathies have multiple disguises and may to a …

The nociceptive system is not fixed, but changes in response to its input and activity. This'
plasticity'comprises dynamic developments of both pro-and antinociceptive processes …

Nociceptive pain alerts the body to potential or actual tissue damage. By contrast,
neuropathic pain, which results from injury or damage to the nervous system, persists long …

Neuropathic pain in humans arises as a consequence of injury or disease of somatosensory
nervous system at peripheral or central level. Peripheral neuropathic pain is more common …

Neuropathic pain is a debilitating form of treatment resistant chronic pain and responds
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …

The mechanisms involved in the development of chronic pain are varied and complex. Pain
processes are plastic and unrelieved pain may lead to changes in the neural structure …

Neuropathic pain in humans arises as a consequence of injury or disease of somatosensory
nervous system at peripheral or central level. Peripheral neuropathic pain is more common …

Neuropathic pain results from damage to the nervous system. The diseases responsible for
neuropathic pain are diverse but they may have in common pathophysiological …