Naturally occurring 8-O-methylated sialic acids, including 8-O-methyl-N-acetylneuraminic
acid and 8-O-methyl-N-glycolylneuraminic acid, along with 8-O-methyl-2-keto-3-deoxy-d …

In order to understand the biological importance of naturally occurring sialic acid variations
on disialyl structures in nature, we developed an efficient two-step multienzyme approach for …

O-Acetylation of sialic acid (Sia) modulates its recognition by sialic acid-binding proteins and
plays an important role in biological and pathological processes. 9-O-Acetylation is the most …

Modifications at the glycerol side chain of sialic acid in sialosides modulate their recognition
by sialic acid-binding proteins and sialidases. However, limited work has been focused on …

Sialic acids (Sias) are important constituents of cell surface glycans. Ready access to Sias in
large quantities would facilitate the development of carbohydrate‐based vaccines and small …

Abstract Naturally occurring 2, 7-anhydro-alpha-N-acetylneuraminic acid (2, 7-anhydro-
Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT …

β-d-Gal p-(1→ 9)-d-KDN, a disaccharide component of the cell wall of Streptomyces sp. MB-
8, was synthesized from β-d-Gal p-(1→ 6)-d-Man p and pyruvate using a sialic acid …

A chemo-enzymatic synthesis of [(5-acetamido-9-O-acetyl-3, 5-dideoxy-d-glycero-α-d-
galacto-2-nonulopyranosylonic acid)-(2→ 3)-O-(β-d-galactopyranosyl)-(1→ 3)-O-(2 …

A novel chemoenzymatic synthon strategy has been developed to construct a
comprehensive library of α2–3-and α2–6-linked sialosides containing 7-N-or 7, 9-di-N-acetyl …

Conspectus Sialic acids are fascinating negatively charged nine-carbon monosaccharides.
Sialic acid-containing glycans and glycoconjugates are structurally diverse, functionally …