AIM: To establish whether chemotherapy-induced neutropenia is predictive of better
outcome in patients with metastatic colorectal cancer (mCRC). METHODS: Survival and …

Purpose: Chemotherapy-induced gastrointestinal (CIGI) toxicity affects the quality of life of
patients with colorectal cancer (CRC) and the clinical application of treatment drugs. This …

Colorectal cancer is currently a public health priority because it is the second leading cause
of cancer deaths in Western countries. Combination regimes of oxaliplatin and infusional …

3537 Background: Oxaliplatin (Eloxatin)/fluoropyrimidine (O/F) combinations are highly
effective in the treatment of CRC, but there is debate about the merits of different …

Background: A dose-finding study was performed to evaluate the dose-limiting toxicity (DLT),
maximum-tolerated dose (MTD) and the recommended dose (RD) of escalating the doses of …

Objective: To access the comparative effectiveness and safety of different oral Chinese
patent medicine (OCPM) versus oxaliplatin-based chemotherapy regimen (C) alone for …

PURPOSE: Irinotecan and oxaliplatin are two new agents with promising activity in
advanced colorectal cancer. Based on preclinical and clinical evidence that both drugs act …

Significant advances in the treatment of colorectal cancer have been observed over the past
several years. With the introduction of oxaliplatin combined with infusional 5-fluorouracil and …

Background The phase II J003 (N= 169) and phase III RECOURSE (N= 800) trials
demonstrated a significant improvement in survival with trifluridine (FTD)/tipiracil (TPI) …

Background: COIN compared first-line continuous chemotherapy with the same
chemotherapy given intermittently or with cetuximab in advanced colorectal cancer (aCRC) …