Risk factors for colorectal cancer have been identified, and significant advances have been
made in understanding the process of colorectal carcinogenesis. The transition from normal …

During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …

Chemoprevention strategies for colorectal cancer have gained increasing attention. Despite
contradictory data regarding the use of micronutrients and antioxidant vitamins as …

Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or
prevent progression or recurrence of cancer. Colorectal cancers result from complex …

Chemopreventive strategies hold substantial promise for reducing the incidence of
colorectal cancer, the second leading cause of cancer-related mortality in the United States …

COX-2 is an isoenzyme of cyclooxygenase that is increased in response to growth factors,
cytokines, and other mitogenic stimuli. Upregulation of COX-2 gene expression and …

Colorectal cancer is the third most incident cancer in the United States and is second only to
lung cancer as a cause of cancer-related mortality. Colorectal cancer develops through a …

Large bowel cancer is not only the third most frequent cancer in the world but is one of the
most common human malignancies in Western countries, including North America. In recent …

Conclusive findings of cardiovascular (CV) toxicity associated with nonsteroidal anti-
inflammatory drugs (NSAID) in two major colorectal-adenoma prevention trials (1, 2) …

Cancer is predicted to become the leading cause of death–surpassing heart disease–by the
end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 …