Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …

Naphthoquinone is a heterocyclic moiety whose natural derivatives are present as bioactive
compounds in many plants and have stimulated a resurgence of interest in the past decades …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-
substituted 1, 4-naphthoquinone derivatives and nifurtimox have been studied. Compared to …

Synthetic and natural naphthofuranquinones were tested in vitro against three Trypanosoma
cruzi strains with different drug susceptibility to nifurtimox and benznidazole in vivo. Four …

A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …

Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids
Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered …

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1, 4-
naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their …

A series of naphthoquinone derivatives has been synthesized and tested for its biological
activity against human African trypanosomiasis. The use of reverse micellar medium not only …

Naphtho [2, 3-b] thiophen-4, 9-quinone and five derivatives were prepared using the Friedel-
Crafts reaction and tandem-lithiation of aromatic diethylamides. These quinones were …