Chagas' disease is caused by unicellular parasite Trypanosoma cruzi (T. cruzi). It is endemic
throughout Latin America, but nowadays has become a global challenge due to tourism and …

The naphthoquinones 2-hydroxy-3-(1, 1-dimethylallyl)-1, 4-naphthoquinone (CS-1),(−)-2, 3,
3-trimethyl-2–3-dihydronaphtho [2, 3-b] furan-4, 9-quinone (CS-3), and 2-acetoxy-3-(1, 1 …

A series of natural products-based phenyl sulfone derivative and their property-based
analogues were investigated as potential growth inhibitors of Trypanosoma brucei …

Several quinoline derivatives incorporating arylnitro and aminochalcone moieties were
synthesized and evaluated in vitro against a broad panel of trypanosomatid protozoan …

Trypanothione reductase (TR) is both a valid and an attractive target for the design of new
trypanocidal drugs. Starting from menadione, plumbagin, and juglone, three distinct series of …

The neglected infection known as Chagas disease, caused by the protozoan parasite
Trypanosoma cruzi, results in more than 7000 deaths per year, with an increasing number of …

Abstract Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which
are caused by the trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and …

Ten 5-nitro-2-furyl derivatives, with good to excellent in vitro anti-Trypanosoma cruzi activity,
and nifurtimox were tested oral and intraperitoneally on healthy animals for its acute toxicity …

We report the synthesis and in vitro activity against Trypanosoma cruzi epimastigotes of 15
novel quinoxaline derivatives. Ten of the derivatives presented IC 50 values lower than the …

Lack of much interest by the pharmaceutical industry to venture into development of new anti-
trypanosomal drugs has been a major stimulus to an intensification of research into the few …