Series of 2-exo-aryl-1, 4-epoxy-2, 3, 4, 5-tetrahydronaphtho [1, 2-b] azepines 3a–k and cis-2-
aryl-4-hydroxy-2, 3, 4, 5-tetrahydronaphtho [1, 2-b] azepines 4a–j were synthesized and …

Furanaphthoquinones are well known in medicinal chemistry for exhibiting relevant
structural heterogeneity and bioactivities. In this work, it was synthesized a series of …

The effect of psilostachyin, a natural sesquiterpene lactone, on the growth and viability of
cultured epimastigotes of Trypanosoma cruzi (Tulahuen) is reported. The antiproliferative …

The anti-Trypanosoma cruzi activity of 5-nitro-2-furfuriliden derivatives as well as the
cytotoxicity of these compounds on J774 macrophages cell line and FN1 human fibroblast …

Novel β-lapachone analogs 2-phenyl-3, 4-dihydro-2H-benzo [h] chromene-5, 6-dione
(NQ1), 2-p-tolyl-3, 4-dihydro-2H-benzo [h] chromene-5, 6-dione (NQ3) and 2-methyl-2 …

Chagas disease (CD) is a neglected tropical disease of worldwide health concern, caused
by the flagellate protozoan Trypanosoma cruzi (T. cruzi), endemic in Latin America and …

Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi
that affects millions of people, mainly in Latin America where it is considered endemic. The …

Trypanosoma cruzi is the causative agent of Chagas' disease, an endemic and neglected
disease. The treatment is limited to only two drugs, benznidazole (BZL) and nifurtimox …

Three new series of quinoline, quinolone, and benzimidazole derivatives were synthesized
and evaluated in vitro against Trypanosoma brucei gambiense. In the quinoline series, the …

Background: Chagas disease, also known as American trypanosomiasis, is a potentially life-
threatening illness caused by the protozoan parasite Trypanosoma cruzi. No progress in the …