Discovery of Near-Infrared Heptamethine Cyanine Probes for Imaging-Guided Surgery in Solid Tumors

Q Lin, C Li, Y Wang, Y Zhu, Y Gu - Journal of Medicinal Chemistry, 2024 - ACS Publications
Near-infrared (NIR) fluorescence imaging has attracted much attention in image-guided
interventions with unique advantages. However, the clinical translation rate of fluorescence …

Synthesis and characterization of a glycine-modified heptamethine indocyanine dye for in vivo cancer-targeted near-infrared imaging

T Liu, S Luo, Y Wang, X Tan, Q Qi… - … Design, Development and …, 2014 - Taylor & Francis
Near-infrared (NIR) fluorescent sensors have emerged as promising molecular tools for
cancer imaging and detection in living systems. However, cancer NIR fluorescent sensors …

Recent progress on near‐infrared fluorescence heptamethine cyanine dye‐based molecules and nanoparticles for tumor imaging and treatment

Y Qiu, B Yuan, Y Cao, X He, OU Akakuru… - Wiley …, 2023 - Wiley Online Library
Recenly, near‐infrared fluorescence heptamethine cyanine dyes have shown satisfactory
values in bioengineering, biology, and pharmacy especially in cancer diagnosis and …

A near-infrared fluorescent heptamethine indocyanine dye with preferential tumor accumulation for in vivo imaging

C Zhang, T Liu, Y Su, S Luo, Y Zhu, X Tan, S Fan… - Biomaterials, 2010 - Elsevier
Near-infrared (NIR) fluorescence imaging holds great promise for tumor imaging due to low
tissue autofluorescence and deep tissue penetration. However, most tumor-targeting …

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

C Shi, JB Wu, D Pan - Journal of biomedical optics, 2016 - spiedigitallibrary.org
A class of near-infrared fluorescence (NIRF) heptamethine cyanine dyes that are taken up
and accumulated specifically in cancer cells without chemical conjugation have recently …

Near-infrared asymmetrical heptamethine cyanines specifically imaging cancer cells by sensing their acidic lysosomal lumen

R Xi, J Zhang, Y Zhang, S Li, Y Li, X Li, L Chen, C Li - RSC advances, 2016 - pubs.rsc.org
Tumor cytoreductive surgery faces great challenges to completely remove malignant
residues due to the indistinct margin between the normal and neoplastic tissues. Intra …

[HTML][HTML] Heptamethine carbocyanine DZ-1 dye for near-infrared fluorescence imaging of hepatocellular carcinoma

J An, N Zhao, C Zhang, Y Zhao, D Tan, Y Zhao, B Bai… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Near-infrared fluorescence (NIRF) dyes have recently emerged as promising tools for non-
invasive imaging of different types of cancers. Here, we explored the potential utility of a …

Synthesis of near-infrared heptamethine cyanine dyes

JL Gragg - 2010 - scholarworks.gsu.edu
Carbocyanine dyes are organic compounds containing chains of conjugated methine
groups with electron-donating and electron-withdrawing substituents at the terminal …

Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes

C Canovas, PS Bellaye, M Moreau, A Romieu… - Organic & …, 2018 - pubs.rsc.org
Near-infrared (NIR) fluorescence imaging is a promising new medical imaging modality.
Associated with a targeting molecule, NIR fluorophores can accumulate selectively in …

Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation

X Meng, W Li, Z Sun, J Zhang, L Zhou… - Journal of Materials …, 2017 - pubs.rsc.org
Near-infrared (NIR) organic dyes have received increasing attention in recent years as
diagnostic and therapeutic agents in the field of tumor research. In this study, IR-822, a near …