Cefiderocol is a novel siderophore cephalosporin that forms a complex with extracellular
free ferric iron, which leads to transportation across the outer cell membrane to exert its …

ABSTRACT Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin
conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent …

Cefiderocol is a siderophore cephalosporin in development for treatment of infections
caused by Gram-negative bacilli, including carbapenem-resistant and multidrug-resistant …

The in vitro activity of the investigational siderophore cephalosporin, cefiderocol (formerly S-
649266), was determined against a 2014–2016, 52-country, worldwide collection of clinical …

ABSTRACT Cefiderocol (formerly S-649266) is an investigational siderophore
cephalosporin. Iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) was …

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-
resistant Gram-negative bacteria. In this study, the activity of cefiderocol against …

Abstract Multidrug-resistant (MDR) Gram-negative bacteria (GNB) pose a critical threat to
global healthcare, worsening outcomes and increasing mortality among infected patients …

Background New antibiotics are needed for the treatment of patients with life-threatening
carbapenem-resistant Gram-negative infections. We assessed the efficacy and safety of …

The objective of this study was to characterize isolates with reduced susceptibility to
cefiderocol in patients receiving cefiderocol for nosocomial pneumonia or carbapenem …

Cefiderocol, a new injectable siderophore cephalosporin antibiotic, has promising in vitro
and in vivo activity against Gram‐negative bacteria including multidrug‐resistant …