Microbiological, clinical, and PK/PD features of the new anti-Gram-negative antibiotics: β-lactam/β-lactamase inhibitors in combination and cefiderocol—an all …
L Principe, T Lupia, L Andriani, F Campanile… - Pharmaceuticals, 2022 - mdpi.com
Bacterial resistance mechanisms are continuously and rapidly evolving. This is particularly
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …
Defining baseline mechanisms of cefiderocol resistance in the Enterobacterales
The objective of this study was to identify putative mechanisms contributing to baseline
cefiderocol resistance among carbapenem-resistant Enterobacterales (CRE). We evaluated …
cefiderocol resistance among carbapenem-resistant Enterobacterales (CRE). We evaluated …
In Vitro Antibacterial Activity of Cefiderocol against Multidrug-Resistant Acinetobacter baumannii
JC Abdul-Mutakabbir, L Nguyen… - Antimicrobial agents …, 2021 - Am Soc Microbiol
Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity
against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated …
against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated …
Global prevalence of cefiderocol non-susceptibility in Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas maltophilia: a …
S Karakonstantis, M Rousaki, L Vassilopoulou… - Clinical Microbiology …, 2023 - Elsevier
Background Cefiderocol is a last resort option for carbapenem-resistant (CR) Gram-negative
bacteria, especially metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa and …
bacteria, especially metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa and …
[HTML][HTML] In vitro activity of cefiderocol, a siderophore cephalosporin, against Gram-negative bacilli isolated by clinical laboratories in North America and Europe in …
JA Karlowsky, MA Hackel, M Tsuji, Y Yamano… - International journal of …, 2019 - Elsevier
ABSTRACT Cefiderocol (S-649266) is a parenteral siderophore cephalosporin in phase III
of clinical development. In this study, we determined the in vitro susceptibility to cefiderocol …
of clinical development. In this study, we determined the in vitro susceptibility to cefiderocol …
Activity of cefiderocol and comparators against isolates from cancer patients
KVI Rolston, B Gerges, S Shelburne… - Antimicrobial agents …, 2020 - Am Soc Microbiol
ABSTRACT Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients
at≤ 4 mg/liter. It had potent activity against extended-spectrum β-lactamase-positive …
at≤ 4 mg/liter. It had potent activity against extended-spectrum β-lactamase-positive …
Efficacy of humanized exposures of cefiderocol (S-649266) against a diverse population of Gram-negative bacteria in a murine thigh infection model
ML Monogue, M Tsuji, Y Yamano… - Antimicrobial agents …, 2017 - Am Soc Microbiol
ABSTRACT Cefiderocol (S-649266) is a novel siderophore cephalosporin with potent in
vitro activity against clinically encountered multidrug-resistant (MDR) Gram-negative …
vitro activity against clinically encountered multidrug-resistant (MDR) Gram-negative …
In Vitro Susceptibility of Gram-Negative Pathogens to Cefiderocol in Five Consecutive Annual Multinational SIDERO-WT Surveillance Studies, 2014 to 2019
JA Karlowsky, MA Hackel, M Takemura… - Antimicrobial agents …, 2022 - Am Soc Microbiol
We report in vitro susceptibility data from five consecutive annual SIDERO-WT surveillance
studies (2014 to 2019) for cefiderocol and comparators tested against Gram-negative …
studies (2014 to 2019) for cefiderocol and comparators tested against Gram-negative …
Occurrence of high levels of cefiderocol resistance in carbapenem-resistant Escherichia coli before its approval in China: a report from China CRE-network
Q Wang, L Jin, S Sun, Y Yin, R Wang, F Chen… - Microbiology …, 2022 - Am Soc Microbiol
Cefiderocol has been approved in the United States and Europe but not in China. We aim to
evaluate carbapenem-resistant Enterobacterales (CRE) susceptibility to cefiderocol to …
evaluate carbapenem-resistant Enterobacterales (CRE) susceptibility to cefiderocol to …
Stability and low induction propensity of cefiderocol against chromosomal AmpC β-lactamases of Pseudomonas aeruginosa and Enterobacter cloacae
A Ito, T Nishikawa, M Ota, T Ito-Horiyama… - Journal of …, 2018 - academic.oup.com
Objectives The siderophore cephalosporin cefiderocol possesses in vitro activity against
MDR Gram-negative bacteria. The stability of cefiderocol against serine-and metallo-type …
MDR Gram-negative bacteria. The stability of cefiderocol against serine-and metallo-type …