An activating mutation in the BRAF gene is the most common genetic alteration in papillary
thyroid carcinomas (PTCs). The mutation in PTCs is almost a c. 1799T> A transversion …

Activating mutations of the BRAF gene are the most common genetic alterations in papillary
thyroid carcinomas (PTCs) and the T1799A transversion, resulting in BRAF V600E …

To assess the mutational status of BRAF in FVPTC, we directly sequenced the genomic DNA
of 30 primary FVPTC samples. BRAF mutations were found in only 4 (13%) tumors. We also …

A common mutation in the BRAF gene, comprising the T1799A nucleotide transversion,
which leads to the V600E amino acid substitution in the BRAF protein, has been observed in …

Context: Mutations in BRAF are rare in the follicular variant of papillary thyroid carcinoma
(FV-PTC). Objective: We identified and functionally characterized a novel T599I-VKSR (600 …

BRAF, a cytoplasmic serine–threonine protein kinase, plays a critical role in cell signaling as
an activator within the mitogen-activated protein kinase (MAPK) pathway. The most common …

BRAF gene mutations have been frequently detected in papillary thyroid carcinoma (PTC).
Moreover, there is a close association between the type of mutation and the PTC histotype …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy and
includes several histological variants. Patients suffering from PTC usually have a good …

Background: Activating mutations of the BRAF gene have recently been reported in thyroid
carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma …

Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …